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KMID : 0043320090320010049
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Archives of Pharmacal Research
2009 Volume.32 No. 1 p.49 ~ p.57
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Anti-androgen-independent Prostate Cancer Effects of Ginsenoside Metabolites In Vitro: Mechanism and Possible Structure-Activity Relationship Investigation
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Yang Ling
Liu Hui-Xin
Xiang Nan
Ai Chun-Zhi
Zhang Jiang-Wei
Liu Yong
Li Wei
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Abstract
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Treatment of androgen-independent prostate cancer (AIPC) remains unsatisfactory. In our present experiment, natural occurring ginsenosides (NOGs) and intestinal bacterial metabolites (IBMs) were employed to investigate their anti-AIPC cell growth activity using PC-3 cells. Our results showed that the IBMs exerted more portent anti-AIPC activity than NOGs, by decreasing survival rate, inhibiting proliferation, inducing apoptosis, and leading to cell cycle arrest in AIPC PC-3 cells. The increase of LogP and decrease of C-6 steric hindrance, which were caused by deglycosylation by intestinal bacteria, may be the reason for the higher anti-AIPC activity of IBMs.
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KEYWORD
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Ginsenosides, Structure-activity relationship, Anti-androgen-independent prostate cancer, In vitro, Intestinal bacterial metabolites
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